Igkv14-111 Gene Detail

Summary

• Symbol
  Igkv14-111
• Name
  immunoglobulin kappa variable 14-111
• Synonyms
  Gm16939

• Feature Type
  gene segment
• IDs
  MGI:4439863
  NCBI Gene: 545847
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr6:68233388-68233853 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 31.12 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  235 from dbSNP Build 142
• Strain Annotations
  16

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439863	gene segment	Chr6:68233373-68233853 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0000124	gene segment	Chr6:68437207-68437687 (+)
A/J	MGP_AJ_G0000115	gene segment	Chr6:65488426-65488906 (+)
AKR/J	MGP_AKRJ_G0000121	gene segment	Chr6:67485939-67486419 (+)
BALB/cJ	MGP_BALBcJ_G0000108	gene segment	Chr6:65829733-65830213 (+)
C3H/HeJ	MGP_C3HHeJ_G0000143	gene segment	Chr6:116685109-116685589 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000160	gene segment	Chr6:70068795-70069275 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0000121	gene segment	Chr6:67815456-67817942 (+)
CBA/J	MGP_CBAJ_G0000115	gene segment	Chr6:72871988-72872468 (+)
DBA/2J	MGP_DBA2J_G0000110	gene segment	Chr6:65156195-65156675 (+)
FVB/NJ	MGP_FVBNJ_G0000110	gene segment	Chr6:64588063-64588543 (+)
LP/J	MGP_LPJ_G0000127	gene segment	Chr6:68268153-68268633 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000122	gene segment	Chr6:76645378-76645858 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000147	gene segment	Chr6:67521903-67522383 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0000077	gene segment	Chr6:66554659-66955246 (+)
WSB/EiJ	MGP_WSBEiJ_G0000119	gene segment	Chr6:67649064-67649543 (+)

Homology

• Human Ortholog
  IGKV1-27, immunoglobulin kappa variable 1-27

• Vertebrate Orthologs
  7

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  IGKV1-27, immunoglobulin kappa variable 1-27
  
• Synonyms
  A20, IGKV127
• Links
  HGNC:5735

  NCBI Gene ID: 28935

  UniProt: A0A075B6S5

  
  
• Chr Location
  2p11.2; chr2:89213423-89213928 (-)  GRCh38

---

• Human Ortholog
  IGKV1-33, immunoglobulin kappa variable 1-33
  
• Synonyms
  IGKV133, O18
• Links
  HGNC:5737

  NCBI Gene ID: 28933

  
  
• Chr Location
  2p11.2; chr2:89268001-89268506 (-)  GRCh38

---

• Human Ortholog
  IGKV1-37, immunoglobulin kappa variable 1-37 (non-functional)
  
• Synonyms
  IGKV137, O14
• Links
  HGNC:5739

  NCBI Gene ID: 28931

  UniProt: A0A075B6S9

  
  
• Chr Location
  2p11.2; chr2:89297264-89297785 (-)  GRCh38

---

• Human Ortholog
  IGKV1D-33, immunoglobulin kappa variable 1D-33
  
• Synonyms
  IGKV1D33, O8
• Links
  HGNC:5753

  NCBI Gene ID: 28896

  UniProt: P01593

  
  
• Chr Location
  2p11.2; chr2:89913982-89914545 (+)  GRCh38

---

• Human Ortholog
  IGKV1D-37, immunoglobulin kappa variable 1D-37 (non-functional)
  
• Synonyms
  IGKV1D37, O4
• Links
  HGNC:5755

  NCBI Gene ID: 28894

  UniProt: P0DSN7

  
  
• Chr Location
  2p11.2; chr2:89884740-89885216 (+)  GRCh38

---

• Human Ortholog
  IGKV1D-43, immunoglobulin kappa variable 1D-43
  
• Synonyms
  IGKV1D43, L23, L23a
• Links
  HGNC:5758

  NCBI Gene ID: 28891

  UniProt: A0A0B4J1Z2

  
  
• Chr Location
  2p11.2; chr2:90209873-90210529 (+)  GRCh38

---

• MGI Vertebrate Homology
  Igkv14-111 stringent orthology
  6 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: IGKV1-27, IGKV1-33, IGKV1-37, IGKV1D-33, IGKV1D-37, IGKV1D-43
• Gene Tree
  Igkv14-111
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  APF
• Find Mice (IMSR)
  2 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706
• cDNA Data
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  24
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000095771 (Evidence)
• NCBI Gene
  545847

Representative Sequences			Length	Strain/Species
genomic	545847	NCBI Gene Model | MGI Sequence Detail	466	C57BL/6J
transcript	AF139221	GenBank | ENA | DDBJ | MGI Sequence Detail	317	BALB/c
polypeptide	A0A140T8P9	UniProt | EBI | MGI Sequence Detail	117	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR050150 Immunoglobulin Variable Light Chain
  IPR013106 Immunoglobulin V-set domain

Molecular
Reagents

• All nucleic 1

  cDNA 1

References

• Summaries
  All 7

  Gene Ontology 1
• Earliest
  J:164271 Arnhold J, et al., Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys. 2010 Aug 1;500(1):92-106

TSS for Igkv14-111:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56920	Chr6:68233360-68233368 (+)	-24 bp