Tg(CAG-VCP*A232E)93Jpat
Transgene Detail

Summary

• Symbol: Tg(CAG-VCP*A232E)93Jpat
• Name: transgene insertion 93, J Paul Taylor
• MGI ID: MGI:4440440
• Synonyms: VCP-A232E
• Transgene: Tg(CAG-VCP*A232E)93Jpat Location: unknown
• Alliance: Tg(CAG-VCP*A232E)93Jpat page

Transgene origin

• Strain of Origin: SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-VCP*A232E)93Jpat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VCP (7415)

  Vcp	(MGI:99919)

• Mutation details: The CAG promoter was used to drive ubiquitous expression of the human cDNA with a nucleotide substitution resulting in the amino acid substitution of glutamic acid for alanine at position 93 (A232E). Five lines were created with line 93 selected as the representative line. (J:158713)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:158713 Custer SK, et al., Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Hum Mol Genet. 2010 May 1;19(9):1741-55
• All: 4 reference(s)