Tg(Eno2-MFN2*R94Q)L51Ugfm
Transgene Detail

Summary

• Symbol: Tg(Eno2-MFN2*R94Q)L51Ugfm
• Name: transgene insertion L51, University of Geneva Faculty of Medicine
• MGI ID: MGI:4440895
• Synonyms: hMFN2R94QL51, MitoCharc1, mitofusin2R94Q
• Transgene: Tg(Eno2-MFN2*R94Q)L51Ugfm Location: unknown
• Alliance: Tg(Eno2-MFN2*R94Q)L51Ugfm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-MFN2*R94Q)L51Ugfm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MFN2 (9927)

  Mfn2	(MGI:2442230)

• Mutation details: The MitoCharc1 transgene was designed with the human Mitofusin 2 (MNF2) gene driven by a rat enolase (Eno2) promoter. Amino acid 94 of MNF2 was mutated from an Arginine (R) to a Glutamine (Q) to mimic the most commonly mutated residue in Charcot-Marie-Tooth disease type 2A (CMT2A). Line L51 was established. (J:158936)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:158936 University of Geneva Faculty of Medicine, DDS for transgene from Ugfm. MGI Direct Data Submission. 2010
• All: 5 reference(s)