Tg(CAG-FCGRT)276Dcr
Transgene Detail

Summary

• Symbol: Tg(CAG-FCGRT)276Dcr
• Name: transgene insertion 276, Derry C Roopenian
• MGI ID: MGI:4441040
• Synonyms: hFcRn (276) Tg, Tg276
• Transgene: Tg(CAG-FCGRT)276Dcr Location: Chr1:184861574-184861575 bp Genetic Position: Chr1, Syntenic
• Alliance: Tg(CAG-FCGRT)276Dcr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Duplication, Insertion
• Tg(CAG-FCGRT)276Dcr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCGRT (2217)

  Fcgrt

  (MGI:103017)

• Mutation details: To generate the hFcRn line 276 transgenic mice, a transgene was designed with the 0.34 kb human cytomegalovirus immediate early promoter enhancer, 1.4 kb chicken beta-actin promoter and intron 1, a cDNA sequence encoding the human FcRn alpha-chain, 0.73 kb rabbit beta-globin intron, and 0.35 kb SV40 polyA sequence. Line 276 was established. Transgene insertion occurred on Chr 1, causing a 1 bp duplication. (J:110885)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:110885 Chaudhury C, et al., The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003 Feb 3;197(3):315-22
• All: 18 reference(s)