Tg(Flt4-cre)44Ichi
Transgene Detail

Summary

• Symbol: Tg(Flt4-cre)44Ichi
• Name: transgnene insertion 44, Hirotake Ichise
• MGI ID: MGI:4441403
• Synonyms: Vegfr3-Cre
• Transgene: Tg(Flt4-cre)44Ichi Location: unknown
• Alliance: Tg(Flt4-cre)44Ichi page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Flt4-cre)44Ichi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Flt4 (MGI:95561)

• Mutation details: A cDNA encoding nlscre was inserted after 7 kb fragment of the Flt4 (Vegfr3) gene promoter region from the BAC RPC123-118J11 in the targeting vector. The cre sequence was followed by a polyA signal sequence from the murine Pgk gene. This vector was purified and injected into pronuclei of fertilized C57BL/6J mice. Line 44 showed recombination in lymphatic endothelial cells when crossed to reporter mice. (J:159024)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Flt4 (mouse) Summary of all recombinase alleles driven by Flt4. Alliance mouse Flt4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:159024 Ichise T, et al., H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development. 2010 Mar;137(6):1003-13
• All: 2 reference(s)