Tg(Tyr-Th,-Gch1)6775Lmon
Transgene Detail
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Symbol: |
Tg(Tyr-Th,-Gch1)6775Lmon |
Name: |
transgene insertion 6775, Lluis Montoliu |
MGI ID: |
MGI:4443311 |
Synonyms: |
TyrTH |
Transgene: |
Tg(Tyr-Th,-Gch1)6775Lmon Location: unknown
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Alliance: |
Tg(Tyr-Th,-Gch1)6775Lmon page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Tyr-Th,-Gch1)6775Lmon expresses
3 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
mouse |
Gch1 (MGI:95675) |
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Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1. |
mouse |
Th (MGI:98735) |
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Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1. |
rat |
Th (25085) |
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Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1. |
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Mutation details: The mouse Tyr promoter was used to drive expression of a Th chimeric minigene composed of a mouse genomic fragment containing exons 1 and 2, rat cDNA containing sequence from exons 2 to 11, and mouse genomic sequence for exons 11 to 13. The Th minigene is deposited in GenBank as AY855842. An IRES element linked the Th construct to Gch1. Six founders were identified. Founder line 6775 contained four copies of the transgene and expressed the highest eye-specific tyrosine hydroxylase levels.
(J:105984)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:105984 Lavado A, et al., Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin. J Neurochem. 2006 Feb;96(4):1201-11 |
All: |
1 reference(s) |
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