Tg(CYP1A1-PPARD)#Jfoe
Transgene Detail

Summary

• Symbol: Tg(CYP1A1-PPARD)#Jfoe
• Name: transgene insertion, John Foerster
• MGI ID: MGI:4452377
• Transgene: Tg(CYP1A1-PPARD)#Jfoe Location: unknown
• Alliance: Tg(CYP1A1-PPARD)#Jfoe page

Psoriasis-like skin disease in Tg(CYP1A1-PPARD)#Jfoe/0 mice 20 days after GW501516 administration

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: beta-naphthoflavone
• Mutation: Insertion
• Tg(CYP1A1-PPARD)#Jfoe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PPARD (5467)

  Ppard

  (MGI:101884)

• Mutation details: The human promoter drives the inducible expression of the human cDNA. High constitutive sebaceous-specific expression in the absence of activation was observed. No line information was provided (denoted by #). (J:158907)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158907 Romanowska M, et al., Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo. PLoS One. 2010;5(3):e9701
• All: 1 reference(s)