Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd
Transgene Detail
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Symbol: |
Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd |
Name: |
transgene insertion 10395, Bernd Arnold |
MGI ID: |
MGI:3829598 |
Synonyms: |
Des-TCR, Des.TCR, KB5.C20, Tg(KB5.C20-TCR) |
Transgene: |
Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd Location: unknown
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Alliance: |
Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(TcraKB5.C20,TcrbKB5.C20)10395Arnd expresses
2 genes
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Mutation details: The rearranged Tcra and Tcrb genes isolated from the CTL clone KB5.C20 of Bl O.BR (H-2kb) origin were isolated. After insertion of the TCR B enhancer between the rearranged VB and CB sequences, the alpha and beta TCR transgene constructs were coinjected. Ten founders were obtained, which had integrated several copies of both transgenes as judged by Southern blot analysis with alpha and beta chain-specific probes. This line, 10395, show a high percentage of thymocytes that express the clonotype.
(J:28590, J:134775)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Mice carrying this transgene express a T cell receptor (TCR) specific for the mouse MHC class
I molecule H-2Kb and self peptide.
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Original: |
J:134775 Schonrich G, et al., Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell. 1991 Apr 19;65(2):293-304 |
All: |
11 reference(s) |
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