Tg(CD4-CIITA)357Ccum
Transgene Detail

Summary

• Symbol: Tg(CD4-CIITA)357Ccum
• Name: transgene insertion 357, Cheong-Hee Chang
• MGI ID: MGI:4454654
• Synonyms: CIITA Tg, CIITA^Tg
• Transgene: Tg(CD4-CIITA)357Ccum Location: unknown
• Alliance: Tg(CD4-CIITA)357Ccum page

Transgene origin

• Strain of Origin: C57BL/6J x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD4-CIITA)357Ccum expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CIITA (4261)

  Ciita

  (MGI:108445)

• Mutation details: Transgenic mice express a FLAG-tagged type III isoform of human CIITA under the control of a CD4 promoter/enhancer cassette. Expression of the transgene is detected in CD4-positive T cells. An additional line, line 400, was also generated and shows a similar phenotype to line 357. (J:99357)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99357 Patel DR, et al., Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol. 2005 Jan;233(1):30-40
• All: 8 reference(s)