Tg(Ttr-IGF1)1Sykr
Transgene Detail

Summary

• Symbol: Tg(Ttr-IGF1)1Sykr
• Name: transgene insertion 1, Shoshana Yakar
• MGI ID: MGI:4455320
• Synonyms: HIT
• Transgene: Tg(Ttr-IGF1)1Sykr Location: unknown
• Alliance: Tg(Ttr-IGF1)1Sykr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-IGF1)1Sykr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1 (3479)

  Igf1	(MGI:96432)

• Mutation details: The transgene contains the human insulin-like growth factor 1 (IGF1) under the control of the mouse Ttr (transthyretin) promoter. Line 1 was created. (J:157350)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Originally submitted as rat sequence. However, susequent sequencing revealed the promoter to be mouse and the expressed sequence as human.

References

• Original: J:157350 Wu Y, et al., Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice. Endocrinology. 2009 Sep;150(9):4395-403
• All: 9 reference(s)