Tg(Mbp-Pad2)28Fgm
Transgene Detail

Summary

• Symbol: Tg(Mbp-Pad2)28Fgm
• Name: transgene insertion 28, Fabrizio G Mastronardi
• MGI ID: MGI:4459094
• Synonyms: PD2
• Transgene: Tg(Mbp-Pad2)28Fgm Location: unknown
• Alliance: Tg(Mbp-Pad2)28Fgm page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mbp-Pad2)28Fgm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Padi2 (29511)

  Padi2

  (MGI:1338892)

• Mutation details: A 1.9 kb fragment of the mouse Mbp promoter (from the pMG2 plasmid) drives expression of a 2.3 kb cDNA fragment encoding rat Pad2. This line contains 15 copies of the transgene. Immunohistochemical analysis indicates increased expression in the white matter tracts of the corpus callosum. Immunoslot blot analysis of whole brain homogenates also indicates increased expression in mice at 2 to 6 months of age. Myelin samples from the central nervous system contain increased levels of MBP citrullination. (J:142650)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142650 Musse AA, et al., Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech. 2008 Nov;1(4-5):229-40
• All: 2 reference(s)