Tg(LRRK2)WT1Mjfa
Transgene Detail

Summary

• Symbol: Tg(LRRK2)WT1Mjfa
• Name: transgene insertion WT1, Matthew Farrer
• MGI ID: MGI:4460657
• Synonyms: hWT, LRRK2 WT
• Transgene: Tg(LRRK2)WT1Mjfa Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(LRRK2)WT1Mjfa page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LRRK2)WT1Mjfa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: These transgenic mice express the human LRRK2 gene with high levels of protein detected, with an expression pattern similar to that of endogenous mouse Lrrk2. The transgene inserted into Chromosome 12. Transgenic mice express human LRRK2 approximately 20-22 fold over the endogenous mouse Lrrk2 level. Line WT1 was generated. (J:161656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:161656 Farrer MJ, et al., LRRK2 WT BAC transgenic strain. MGI Direct Data Submission. 2010
• All: 8 reference(s)