Tg(LRRK2*G2019S)1Mjfa
Transgene Detail

Summary

• Symbol: Tg(LRRK2*G2019S)1Mjfa
• Name: transgene insertion 1, Matthew Farrer
• MGI ID: MGI:4460658
• Synonyms: LRRK2 GS G2019S
• Transgene: Tg(LRRK2*G2019S)1Mjfa Location: unknown Genetic Position: Chr13, Syntenic
• Alliance: Tg(LRRK2*G2019S)1Mjfa page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LRRK2*G2019S)1Mjfa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: These transgenic mice express the mutant human LRRK2 sequence, 6055G->A transition (G2019S), with high levels of protein detected in an expression pattern similar to that of the endogenous mouse Lrrk2. The transgene inserted into Chromosome 13. Transgenic mice express mutant human LRRK2 at approximately 8-10 fold over the endogenous mouse Lrrk2 level. Line 1 was generated. (J:161657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:161657 Farrer MJ, et al., LRRK2 GS G2019S transgenic strain. MGI Direct Data Submission. 2010
• All: 6 reference(s)