Tg(Igh-V-CD40lg)#Tsub
Transgene Detail

Summary

• Symbol: Tg(Igh-V-CD40lg)#Tsub
• Name: transgene insertion, Takeshi Tsubata
• MGI ID: MGI:4461029
• Synonyms: CD154^TG, CD40L/B
• Transgene: Tg(Igh-V-CD40lg)#Tsub Location: unknown
• Alliance: Tg(Igh-V-CD40lg)#Tsub page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-V-CD40lg)#Tsub expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cd40lg (MGI:88337)

• Mutation details: An Igh-V promoter, the Igh intron enhancer, and the Igk 3' enhancer were used to drive expression of the CD40lg cDNA. (J:128824)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128824 Higuchi T, et al., Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol. 2002 Jan 1;168(1):9-12
• All: 7 reference(s)