Dp(10Prmt2-Pdxk)2Yey Cytogenetic Marker Detail

Summary

• Symbol
  Dp(10Prmt2-Pdxk)2Yey
• Name
  duplication, Chr 10, Y Eugene Yu 2
• Synonyms
  Dp(10)1Yey, Dp(10Prmt2-Pdxk)1Yey, Ts2Yey

• Feature Type
  chromosomal duplication
• IDs
  MGI:4461397

Location &
Maps

• Sequence Map
  Chr10:76043060-78300782 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, Syntenic

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  16 phenotypes from multigenic genotypes
  20 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  3 strains or lines available

References

• Summaries
  All 21

  Diseases 1

  Phenotypes 20
• Earliest
  J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
• Latest
  J:351211 Wu Y, et al., Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. Acta Neuropathol Commun. 2023 Aug 14;11(1):132