Tg(Umod*C147W)958Lura
Transgene Detail

Summary

• Symbol: Tg(Umod*C147W)958Lura
• Name: transgene insertion 958, Luca Rampoldi
• MGI ID: MGI:4819096
• Synonyms: Tg^UmodC147W
• Transgene: Tg(Umod*C147W)958Lura Location: unknown
• Alliance: Tg(Umod*C147W)958Lura page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Umod*C147W)958Lura expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Umod (MGI:102674)

• Mutation details: The transgene minigene contains a 2.9 kb fragment of the promoter the first non-coding exon and intron 1, the remaining coding sequence from exon 2 through 11 with nucleotide substitutions that result in the amino acid substitution of tryptophan for cysteine at position 147 (C147W), and the entire 3'UTR. Line 958 was generated. (J:161532)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:161532 Bernascone I, et al., A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure. Hum Mol Genet. 2010 Aug 1;19(15):2998-3010
• All: 4 reference(s)