Tg(PMP22)C61Clh
Transgene Detail

Summary

• Symbol: Tg(PMP22)C61Clh
• Name: transgene insertion C61, Clare Huxley
• MGI ID: MGI:4819405
• Transgene: Tg(PMP22)C61Clh Location: unknown Genetic Position: Chr10, Syntenic
• Alliance: Tg(PMP22)C61Clh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PMP22)C61Clh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PMP22 (5376)

  Pmp22

  (MGI:97631)

• Mutation details: A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Lines C1, C2, C16, C22, C58, and C61 were generated. (J:77330, J:78221)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77330 Huxley C, et al., Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. Hum Mol Genet. 1998 Mar;7(3):449-58
• All: 10 reference(s)