Tg(Myh6-TNNT2*R141W)#Ajm
Transgene Detail

Summary

• Symbol: Tg(Myh6-TNNT2*R141W)#Ajm
• Name: transgene insertion, Ali J Marian
• MGI ID: MGI:4819721
• Synonyms: cTnT-W141
• Transgene: Tg(Myh6-TNNT2*R141W)#Ajm Location: unknown
• Alliance: Tg(Myh6-TNNT2*R141W)#Ajm page

Transgene origin

• Strain of Origin: C3H and C57BL/6 and ICR

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TNNT2*R141W)#Ajm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNNT2 (7139)

  Tnnt2

  (MGI:104597)

• Mutation details: This transgene consists of a 5.5 Kb fragment of the murine Myh6 promoter driving expression of a full length human TNNT2 cDNA containing a substitution that results in an Arg 141 Trp mutation. (J:161899)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:161899 Lombardi R, et al., Differential interactions of thin filament proteins in two cardiac troponin T mouse models of hypertrophic and dilated cardiomyopathies. Cardiovasc Res. 2008 Jul 1;79(1):109-17
• All: 1 reference(s)