Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
Transgene Detail

Summary

• Symbol: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
• Name: transgene insertion M-2, Ali J Marian
• MGI ID: MGI:4819719
• Synonyms: cTnT-Q92
• Transgene: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm Location: unknown
• Alliance: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm page

Transgene origin

• Strain of Origin: C3H and C57BL/6 and ICR

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tnnt2-TNNT2*R92Q)M-2Ajm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNNT2 (7139)

  Tnnt2

  (MGI:104597)

• Mutation details: This transgene consists of a -497 bp fragment of the mouse Tnnt2 promoter driving expression of a full length human TNNT2 cDNA containing a G to A substitution that results in an Arg 92 Gln mutation. Five lines were generated (M-1, M-2, M-3, M-4. M-5). In this line (M-2) transgene transcript and protein make up 15% and 9%, respectively, of the total TNNT2 pool. (J:117554)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117554 Oberst L, et al., Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice. J Clin Invest. 1998 Oct 15;102(8):1498-505
• All: 2 reference(s)