Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Transgene Detail

Summary

• Symbol: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
• Name: transgene insertion, Carlo M Croce
• MGI ID: MGI:4820820
• Synonyms: Emu-miR-29, Tg(Emu-Mir29a,-Mir29b-1,-hrGFP)#Cro
• Transgene: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro Location: unknown
• Alliance: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir29a (MGI:2676904)
  mouse	Mir29b-1 (MGI:2676905)

• Mutation details: The mouse Igh (VH186.2) promoter and the IgH-E mu enhancer drive the expression of Mir29a and Mir29b-1, followed by an IRES-hrGFP, humanized renilla, and the SV40 poly (A).Northern blot analysis using RNAs isolated from spleens showed overexpression of Mir-29a and Mir-29b-1 in both transgenic lines (F1 and F2). This line is a represntative line. (J:162077)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:162077 Santanam U, et al., Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12210-5
• All: 2 reference(s)