Tg(CMV-ATXN3*83Q)83Pama
Transgene Detail

Summary

• Symbol: Tg(CMV-ATXN3*83Q)83Pama
• Name: transgene insertion 83, Patricia Maciel
• MGI ID: MGI:4822568
• Synonyms: CMVMJD83
• Transgene: Tg(CMV-ATXN3*83Q)83Pama Location: unknown
• Alliance: Tg(CMV-ATXN3*83Q)83Pama page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-ATXN3*83Q)83Pama expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

  Transgene codes for a protein with an expanded repeat of 83 glutamines.

• Mutation details: The CMV promoter drives expression of the human cDNA with an expansion of the CAG trinucleotide repeat to code for 83 glutamines. One line (83) was generated. (J:163032)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:163032 Silva-Fernandes A, et al., Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products. Neurobiol Dis. 2010 Oct;40(1):163-176
• All: 1 reference(s)