Tg(MMTV-LPAR1)#Gbm
Transgene Detail

Summary

• Symbol: Tg(MMTV-LPAR1)#Gbm
• Name: transgene insertion, Gordon B Mills
• MGI ID: MGI:4835229
• Transgene: Tg(MMTV-LPAR1)#Gbm Location: unknown
• Alliance: Tg(MMTV-LPAR1)#Gbm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-LPAR1)#Gbm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LPAR1 (1902)

  Lpar1

  (MGI:108429)

• Mutation details: The MMTV-lpa1 transgenic construct contains the 1.54 kb MMTV LTR and the full-length cDNA of FLAG-tagged human LPA1 receptor linked to the KCR fragment containing the exon II (E2), intron II (I2), exon III (E3), and polyadenylation signal (rbGpA) derived from rabbit beta-globin. Three MMTV-lpa1 (#LPA1-2, #LPA1-7, and #LPA1-27) founders passed the transgene through the germ line. (J:149661)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-LPAR1)#Gbm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149661 Liu S, et al., Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 2;15(6):539-50
• All: 2 reference(s)