Tg(tetO-Bmpr2*R899X)#Jwst
Transgene Detail

Summary

• Symbol: Tg(tetO-Bmpr2*R899X)#Jwst
• Name: transgene insertion, James West
• MGI ID: MGI:4838675
• Synonyms: TetO7-BMPR2^R899X
• Transgene: Tg(tetO-Bmpr2*R899X)#Jwst Location: unknown
• Alliance: Tg(tetO-Bmpr2*R899X)#Jwst page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Bmpr2*R899X)#Jwst expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmpr2 (MGI:1095407)

• Mutation details: A septad of tetracycline response element with a minimal CMV promoter drive inducible expression of the mouse cDNA with nucleotide substitutions that result in the amino acid substitution of a stop codon for arginine at position 899 (R899X). The cDNA has a C-terminal FLAG tag and is followed by the beta-globin intron and polyadenylation sequence. The amino acid substitution does not alter SMAD activity. No line number or name was provided (designated by #). (J:142266)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:142266 West J, et al., Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55
• All: 15 reference(s)