Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Transgene Detail

Summary

• Symbol: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
• Name: transgene insertion 110, David R Borchelt
• MGI ID: MGI:4849838
• Transgene: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo Location: unknown
• Alliance: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The mouse promoter drives neuronal expression of human SOD1 containing the G37R mutation found in patients with familial amyotrophic lateral sclerosis. This transgene was co-injected with Tg(PSEN1)S8-4Dbo. Two lines were generated (39 and 110). (J:104655)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104655 Wang J, et al., Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA. Neurobiol Dis. 2005 Dec;20(3):943-52
• All: 4 reference(s)