Tg(Igh-TCL1A)1Ypek
Transgene Detail

Summary

• Symbol: Tg(Igh-TCL1A)1Ypek
• Name: transgene insertion 1, Yuri Pekarsky
• MGI ID: MGI:4850003
• Synonyms: Emu-TCL1FL
• Transgene: Tg(Igh-TCL1A)1Ypek Location: unknown
• Alliance: Tg(Igh-TCL1A)1Ypek page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-TCL1A)1Ypek expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TCL1A (8115)

  Tcl1	(MGI:1097166)

• Mutation details: A 1.3 kb fragment encoding the entire human TCL1A coding region and both 5' and 3' UTR was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. The Emu enhancer drives B cell-specific expression. Two lines were generated (lines 1 and 4). (J:160184)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160184 Efanov A, et al., CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia. 2010 May;24(5):970-5
• All: 3 reference(s)