Tg(Igh-TCL1A)1Ypek
Transgene Detail

Summary

• Symbol: Tg(Igh-TCL1A)1Ypek
• Name: transgene insertion 1, Yuri Pekarsky
• MGI ID: MGI:4850003
• Synonyms: Emu-TCL1FL
• Transgene: Tg(Igh-TCL1A)1Ypek Location: unknown
• Alliance: Tg(Igh-TCL1A)1Ypek page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-TCL1A)1Ypek expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TCL1A (8115)

  Tcl1	(MGI:1097166)

• Mutation details: A 1.3 kb fragment encoding the entire human TCL1A coding region and both 5' and 3' UTR was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. The Emu enhancer drives B cell-specific expression. Two lines were generated (lines 1 and 4). (J:160184)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Igh-TCL1A)1Ypek/0	FVB/N-Tg(Igh-TCL1A)1Ypek

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
growth/size/body	√
enlarged spleen	√
hematopoietic system	√
enlarged spleen	√
abnormal lymphocyte physiology	√
decreased IgG1 level	√
decreased IgG2a level	√
decreased IgG2b level	√
decreased IgG3 level	√
decreased IgM level	√
homeostasis/metabolism	√
abnormal circulating chemokine level	√
increased circulating tumor necrosis factor level	√
immune system	√
enlarged spleen	√
abnormal lymphocyte physiology	√
decreased IgG1 level	√
decreased IgG2a level	√
decreased IgG2b level	√
decreased IgG3 level	√
decreased IgM level	√
abnormal circulating chemokine level	√
increased circulating tumor necrosis factor level	√
abnormal humoral immune response	√
neoplasm	√
increased chronic lymphocytic leukemia incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
chronic lymphocytic leukemia IDs chronic lymphocytic leukemia       DOID:1040 EFO:0000095 ICD10CM:C91.10 ICD9CM:204.1 MESH:D015451 NCI:C3163 OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559 ORDO:67038 UMLS_CUI:C0023434 Close	√

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160184 Efanov A, et al., CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia. 2010 May;24(5):970-5
• All: 3 reference(s)