Tg(DYRK1A)36Wjs
Transgene Detail

Summary

• Symbol: Tg(DYRK1A)36Wjs
• Name: transgene insertion 36, Woo-Joo Song
• MGI ID: MGI:4867514
• Synonyms: DYRK1A BAC TG
• Transgene: Tg(DYRK1A)36Wjs Location: unknown
• Alliance: Tg(DYRK1A)36Wjs page

Transgene origin

• Strain of Origin: C57BL/6NCrjBgi

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DYRK1A)36Wjs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DYRK1A (1859)

  Dyrk1a

  (MGI:1330299)

• Mutation details: This transgene consists of a bacterial artificial chromosome clone containing the complete human DYRK1A genomic DNA fragment, including the endogenous promoter (777J19 BAC clone from the RPCI-11 human BAC library). FISH and quantitative PCR analysis shows a single chromosomal integration of the DNA and about a 1.5-fold overexpression of total Dyrk1a (both mouse and human) protein. Two lines 36 and 46 were created, with line 36 entered as the representative line. (J:111293)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:111293 Ahn KJ, et al., DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiol Dis. 2006 Jun;22(3):463-72
• All: 8 reference(s)