Rr10 Other Genome Feature Detail

Summary

• Symbol
  Rr10
• Name
  regulatory region 10
• Synonyms
  HS4

• Feature Type
  enhancer
• IDs
  MGI:4880770

Location &
Maps

• Sequence Map
  Chr11:53500079-53501293 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:167446 homology arm edges: chr11:53500079-53501293

• Genetic Map
  Chromosome 11, Syntenic

Strain
Comparison

• SNPs within 2kb
  159 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a knock-out allele exhibit normal IL4 production.

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:167446 Tanaka S, et al., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol. 2011 Jan;12(1):77-85
• Latest
  J:181626 Harada Y, et al., The 3' Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells. Immunity. 2012 Feb 24;36(2):188-200