Spmip2 MGI Mouse Gene Detail - MGI:4936993 - sperm microtubule inner protein 2

Symbol

Spmip2
Name

sperm microtubule inner protein 2
Synonyms

Gm17359

Feature Type

protein coding gene
IDs

MGI:4936993
NCBI Gene: 100233207
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:79243968-79371436 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 34.91 cM
Mapping Data

1 experiment

SNPs within 2kb

3754 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4936993	protein coding gene	Chr3:79243937-79371436 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027311	protein coding gene	Chr3:79002427-79153363 (+)
A/J	MGP_AJ_G0027273	protein coding gene	Chr3:76447633-76575977 (+)
AKR/J	MGP_AKRJ_G0027241	protein coding gene	Chr3:78198970-78349591 (+)
BALB/cJ	MGP_BALBcJ_G0027284	protein coding gene	Chr3:76476699-76605559 (+)
C3H/HeJ	MGP_C3HHeJ_G0027028	protein coding gene	Chr3:78536867-78668350 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027730	protein coding gene	Chr3:82045430-82179619 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025083	protein coding gene	Chr3:72089107-72219422 (+)
CAST/EiJ	MGP_CASTEiJ_G0026475	protein coding gene	Chr3:78594227-78725599 (+)
CBA/J	MGP_CBAJ_G0027003	protein coding gene	Chr3:84741467-84896250 (+)
DBA/2J	MGP_DBA2J_G0027139	protein coding gene	Chr3:76008631-76134652 (+)
FVB/NJ	MGP_FVBNJ_G0027107	protein coding gene	Chr3:74349442-74475670 (+)
LP/J	MGP_LPJ_G0027247	protein coding gene	Chr3:79995270-80129513 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027126	protein coding gene	Chr3:91015649-91157263 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027788	protein coding gene	Chr3:78037027-78174882 (+)
PWK/PhJ	MGP_PWKPhJ_G0026209	protein coding gene	Chr3:75753996-75888464 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026025	protein coding gene	Chr3:77190168-77319147 (+)
WSB/EiJ	MGP_WSBEiJ_G0026553	protein coding gene	Chr3:78370687-78500588 (+)

Human Ortholog

SPMIP2, sperm microtubule inner protein 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPMIP2, sperm microtubule inner protein 2
Synonyms

C4orf45
Links

HGNC:26342

NCBI Gene ID: 152940

neXtProt AC: NX_Q96LM5

UniProt: Q96LM5
Chr Location

4q32.1; chr4:158893134-159082885 (-) GRCh38

MGI Vertebrate Homology

Spmip2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPMIP2
Gene Tree

Spmip2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Spmip2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

42
RefSeq

10
UniProt

3
CCDS

CCDS50933.1, CCDS89638.1

Ensembl

ENSMUSG00000091685 (Evidence)
NCBI Gene

100233207

			Length	Strain/Species	Flank
genomic	ENSMUSG00000091685	Ensembl Gene Model \| MGI Sequence Detail	127469	C57BL/6J	± kb
transcript	ENSMUST00000199658	Ensembl \| MGI Sequence Detail	1819	Not Applicable
polypeptide	ENSMUSP00000142709	Ensembl \| MGI Sequence Detail	487	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR027814 Protein of unknown function DUF4562

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All nucleic 3

cDNA 3

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MGI:7470723

Summaries

All 22

Developmental Gene Expression 1

Diseases 1

Phenotypes 13
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spmip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29576	Chr3:79243929-79243953 (+)	-27 bp
Tssr29577	Chr3:79243957-79243993 (+)	7 bp
Tssr29578	Chr3:79243995-79244002 (+)	31 bp
Tssr29579	Chr3:79252643-79252656 (+)	8,682 bp
Tssr29580	Chr3:79252668-79252687 (+)	8,710 bp
Tssr29581	Chr3:79325780-79325782 (+)	81,813 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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