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Dthd1 Gene Detail
Summary
  • Symbol
    Dthd1
  • Name
    death domain containing 1
  • Synonyms
    Gm17384
  • Feature Type
    protein coding gene
  • IDs
    MGI:4937018
    NCBI Gene: 100322896
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:62969017-63045651 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4937018
 protein coding gene Chr5:62968999-63045661 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029561
 protein coding gene Chr5:62354011-62434652 (+)
A/J MGP_AJ_G0029529
 protein coding gene Chr5:59986422-60058726 (+)
AKR/J MGP_AKRJ_G0029477
 protein coding gene Chr5:61875244-61952212 (+)
BALB/cJ MGP_BALBcJ_G0029538
 protein coding gene Chr5:60675963-60748207 (+)
C3H/HeJ MGP_C3HHeJ_G0029261
 protein coding gene Chr5:62211303-62286539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029992
 protein coding gene Chr5:64940349-65019694 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027232
 protein coding gene Chr5:56201628-56270871 (+)
CAST/EiJ MGP_CASTEiJ_G0028669
 protein coding gene Chr5:61301692-61379702 (+)
CBA/J MGP_CBAJ_G0029230
 protein coding gene Chr5:67004224-67090909 (+)
DBA/2J MGP_DBA2J_G0029376
 protein coding gene Chr5:60048156-60123472 (+)
FVB/NJ MGP_FVBNJ_G0029336
 protein coding gene Chr5:59247998-59323250 (+)
LP/J MGP_LPJ_G0029461
 protein coding gene Chr5:62807848-62882370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029364
 protein coding gene Chr5:69836897-69927068 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030025
 protein coding gene Chr5:61608749-61694800 (+)
PWK/PhJ MGP_PWKPhJ_G0028393
 protein coding gene Chr5:59068270-59138866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028227
 protein coding gene Chr5:60952374-61027520 (+)
WSB/EiJ MGP_WSBEiJ_G0028750
 protein coding gene Chr5:61777118-61863501 (+)



Homology
more
  • Human Ortholog
    DTHD1, death domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTHD1, death domain containing 1
  • Links
    NCBI Gene ID: 401124
    neXtProt AC: NX_Q6ZMT9
    UniProt: Q6ZMT9

  • Chr Location
    4p14; chr4:36281616-36347511 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000090326 Ensembl Gene Model | MGI Sequence Detail 76635 C57BL/6J ±  kb
transcript ENSMUST00000238474 Ensembl | MGI Sequence Detail 2877 Not Applicable  
polypeptide ENSMUSP00000158635 Ensembl | MGI Sequence Detail 905 Not Applicable  
For the selected sequence
Protein
Information
less
References
more
  • Summaries
    All 29
    Phenotypes 22
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory