Tg(Ins2-Hnf1a)#Cbw
Transgene Detail

Summary

• Symbol: Tg(Ins2-Hnf1a)#Cbw
• Name: transgene insertion, Claes B Wollheim
• MGI ID: MGI:4942165
• Synonyms: RIP-DNHNF1alpha
• Transgene: Tg(Ins2-Hnf1a)#Cbw Location: unknown
• Alliance: Tg(Ins2-Hnf1a)#Cbw page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Hnf1a)#Cbw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hnf1a

• Mutation details: The rat promoter drives beta cell expression of a cDNA for a dominant negative product that lacks 83 amino acids in the DNA-binding domain. (J:134757)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134757 Hagenfeldt-Johansson KA, et al., Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice. Endocrinology. 2001 Dec;142(12):5311-20
• All: 2 reference(s)