Tg(Prnp-SNCA*A53T)25Mkle
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA*A53T)25Mkle
• Name: transgene insertion 25, Michael K Lee
• MGI ID: MGI:4942280
• Synonyms: A53T, N2-5, Tg(Prnp-SNCA*A53T)BAub
• Transgene: Tg(Prnp-SNCA*A53T)25Mkle Location: unknown
• Alliance: Tg(Prnp-SNCA*A53T)25Mkle page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA*A53T)25Mkle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene contains a human alpha synuclein cDNA encoding the Ala53Thr amino acid substitution, and the murine prion promoter. Lines G2-3, H5, and N2-5 were generated (J:77344)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77344 Lee MK, et al., Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73
• All: 6 reference(s)