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Tg(Kit*D814V)3Roer
Transgene Detail
Summary
Symbol: Tg(Kit*D814V)3Roer
Name: transgene insertion 3, Axel Roers
MGI ID: MGI:4942359
Synonyms: kitD814Vflox
Transgene: Tg(Kit*D814V)3Roer  Location: unknown  
Alliance: Tg(Kit*D814V)3Roer page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Kit*D814V)3Roer expresses 1 gene
 
Mutation detailsThis transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries 2 copies of the transgene. Analysis of the residual vector backbone indicates the transgenes in this line may not be intact. (J:169611)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:169611 Gerbaulet A, et al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011 Feb 10;117(6):2012-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory