Tg(Kit*D814V)3Roer
Transgene Detail
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Symbol: |
Tg(Kit*D814V)3Roer |
Name: |
transgene insertion 3, Axel Roers |
MGI ID: |
MGI:4942359 |
Synonyms: |
kitD814Vflox |
Transgene: |
Tg(Kit*D814V)3Roer Location: unknown
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Alliance: |
Tg(Kit*D814V)3Roer page
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Transgene Type: |
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Transgenic (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Kit*D814V)3Roer expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Kit (MGI:96677) |
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Mutation details: This transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries 2 copies of the transgene. Analysis of the residual vector backbone indicates the transgenes in this line may not be intact.
(J:169611)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:169611 Gerbaulet A, et al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011 Feb 10;117(6):2012-21 |
All: |
1 reference(s) |
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