Tg(FCGRT)32Dcr
Transgene Detail
|
Symbol: |
Tg(FCGRT)32Dcr |
Name: |
transgene insertion 32, Derry C Roopenian |
MGI ID: |
MGI:4944199 |
Synonyms: |
hFcRn(32) vhFcRn (32) Tg hFcRn (32) Tg, Tg32 |
Transgene: |
Tg(FCGRT)32Dcr Location: Chr2:100912057-100912058 bp Genetic Position: Chr2, Syntenic
|
Alliance: |
Tg(FCGRT)32Dcr page
|
|
|
Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(FCGRT)32Dcr expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FCGRT (2217) |
|
|
|
|
|
Mutation details: A 34Kb fragment of a BAC containing the entire human FCGRT , Fc fragment of IgG, receptor, transporter, alpha, gene (approximately 11kb) and approximately 10kb of flanking sequence was sublconed into a SuperCos vector. The resulting cosmid was microinjected into fertilized C57BL/6J mouse eggs. Founder line 32 was established. Transgene insertion occurred on Chr 2.
(J:94189, J:133048)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 9 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:133048 Petkova SB, et al., Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol. 2006 Dec;18(12):1759-69 |
All: |
26 reference(s) |
|