Tg(FCGRT)32Dcr
Transgene Detail

Summary

• Symbol: Tg(FCGRT)32Dcr
• Name: transgene insertion 32, Derry C Roopenian
• MGI ID: MGI:4944199
• Synonyms: hFcRn(32) vhFcRn (32) Tg hFcRn (32) Tg, Tg32
• Transgene: Tg(FCGRT)32Dcr Location: Chr2:100912057-100912058 bp Genetic Position: Chr2, Syntenic
• Alliance: Tg(FCGRT)32Dcr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FCGRT)32Dcr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCGRT (2217)

  Fcgrt

  (MGI:103017)

• Mutation details: A 34Kb fragment of a BAC containing the entire human FCGRT , Fc fragment of IgG, receptor, transporter, alpha, gene (approximately 11kb) and approximately 10kb of flanking sequence was sublconed into a SuperCos vector. The resulting cosmid was microinjected into fertilized C57BL/6J mouse eggs. Founder line 32 was established. Transgene insertion occurred on Chr 2. (J:94189, J:133048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available

References

• Original: J:133048 Petkova SB, et al., Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol. 2006 Dec;18(12):1759-69
• All: 32 reference(s)