Mir378b Gene Detail

Summary

• Symbol
  Mir378b
• Name
  microRNA 378b
• Synonyms
  mmu-mir-378b

• Feature Type
  miRNA gene
• IDs
  MGI:4950393
  NCBI Gene: 100628571
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr11:88243599-88243690 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 52.40 cM

Strain
Comparison

• SNPs within 2kb
  53 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4950393	miRNA gene	Chr11:88243599-88243690 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007860	miRNA gene	Chr11:90070824-90070915 (+)
A/J	MGP_AJ_G0007853	miRNA gene	Chr11:86572856-86572947 (+)
AKR/J	MGP_AKRJ_G0007828	miRNA gene	Chr11:89202904-89202995 (+)
BALB/cJ	MGP_BALBcJ_G0007832	miRNA gene	Chr11:86987145-86987236 (+)
C3H/HeJ	MGP_C3HHeJ_G0007778	miRNA gene	Chr11:89233284-89233375 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008011	miRNA gene	Chr11:92812763-92812854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007152	miRNA gene	Chr11:83590433-83590524 (+)
CAST/EiJ	MGP_CASTEiJ_G0007672	miRNA gene	Chr11:89913640-89913731 (+)
CBA/J	MGP_CBAJ_G0007749	miRNA gene	Chr11:96740527-96740618 (+)
DBA/2J	MGP_DBA2J_G0007784	miRNA gene	Chr11:86130788-86130879 (+)
FVB/NJ	MGP_FVBNJ_G0007803	miRNA gene	Chr11:85634931-85635022 (+)
LP/J	MGP_LPJ_G0007862	miRNA gene	Chr11:90587435-90587526 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007773	miRNA gene	Chr11:96735956-96736047 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008007	miRNA gene	Chr11:89420141-89420232 (+)
PWK/PhJ	MGP_PWKPhJ_G0007599	miRNA gene	Chr11:86972626-86972717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007494	miRNA gene	Chr11:89009877-89009968 (+)
WSB/EiJ	MGP_WSBEiJ_G0007739	miRNA gene	Chr11:89314519-89314610 (+)

Homology

• Gene Tree
  Mir378b
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  10 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  4 involving Mir378b
• Find Mice (IMSR)
  0 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Females with a null allele are unable to clear Chlamydia infection and have higher bacterial burden during infection, however mice show reduced uterine pathology, protection from Chlamydia-induced infertility, and reduced proinflammatory immune response following infection.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  23
• RefSeq
  1

• Ensembl
  ENSMUSG00000092985 (Evidence)
• NCBI Gene
  100628571

Representative Sequences			Length	Strain/Species
genomic	100628571	NCBI Gene Model | MGI Sequence Detail	92	C57BL/6J
transcript	NR_039545	RefSeq | MGI Sequence Detail	92	ZRU/MplStud

Other Database
Links

miRBase

MI0016973

References

• Summaries
  All 15

  Diseases 1

  Gene Ontology 1

  Phenotypes 10
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:307588 Lundy SR, et al., MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology. Pathogens. 2021 May 7;10(5)