Tg(tetO-TARDBP*)4Vle
Transgene Detail

Summary

• Symbol: Tg(tetO-TARDBP*)4Vle
• Name: transgene insertion 4, Virginia M Y Lee
• MGI ID: MGI:5000261
• Synonyms: hTDP-43deltaNLS4
• Transgene: Tg(tetO-TARDBP*)4Vle Location: unknown
• Alliance: Tg(tetO-TARDBP*)4Vle page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-TARDBP*)4Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The tetracycline responsive promoter drives inducible expression of the human cDNA lacking the nuclear localization signal. Two lines were generated (4 and 19). (J:170756)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:170756 Igaz LM, et al., Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb 1;121(2):726-38
• All: 19 reference(s)