Tg(tetO-TARDBP)12Vle
Transgene Detail

Summary

• Symbol: Tg(tetO-TARDBP)12Vle
• Name: transgene insertion 12, Virginia M Y Lee
• MGI ID: MGI:5000260
• Synonyms: hTDP-43-WT12
• Transgene: Tg(tetO-TARDBP)12Vle Location: unknown
• Alliance: Tg(tetO-TARDBP)12Vle page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-TARDBP)12Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The tetracycline responsive promoter drives inducible expression of the wild-type human cDNA. Four lines were generated (4, 5, 8, and 12). (J:170756)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1  Disease Model	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-TARDBP)12Vle/0	involves: C3H/HeJ * C57BL/6J
cx2	Tg(NEFH-tTA)8Vle/0 Tg(tetO-TARDBP)12Vle/0	involves: C3H/HeJ * C57BL/6J

Phenotypes:

Affected Systems	cx1	cx2
show or hide all annotated terms
behavior/neurological	√
limb grasping	√
cellular	√
astrocytosis	√
microgliosis	√
hematopoietic system	√
microgliosis	√
immune system	√
microgliosis	√
nervous system	√	√
astrocytosis	√
microgliosis	√
decreased brain weight	√
abnormal dentate gyrus morphology	√
neuronal intranuclear inclusions		√
neurodegeneration	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx1
amyotrophic lateral sclerosis type 10 IDs amyotrophic lateral sclerosis type 10       DOID:0060201 OMIM:612069 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:170756 Igaz LM, et al., Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb 1;121(2):726-38
• All: 7 reference(s)