Tg(LRRK2*Y1699C)#aMjfa
Transgene Detail

Summary

• Symbol: Tg(LRRK2*Y1699C)#aMjfa
• Name: transgene insertion #a, Matthew Farrer
• MGI ID: MGI:5008462
• Transgene: Tg(LRRK2*Y1699C)#aMjfa Location: unknown
• Alliance: Tg(LRRK2*Y1699C)#aMjfa page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(LRRK2*Y1699C)#aMjfa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: The transgene contains nucleotide substitutions that result in the amino acid substitution of cysteine for tyrosine at position 1699 (Y1699C). The pound symbol (#a) was used to represent the unnamed line with 11-fold increased expression. (J:172418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:172418 Dachsel JC, et al., A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5
• All: 1 reference(s)