Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan
Transgene Detail

Summary

• Symbol: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan
• Name: transgene insertion 1, Julie K Andersen
• MGI ID: MGI:5014211
• Transgene: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan Location: unknown
• Alliance: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAOB (4129)

  Maob	(MGI:96916)

• Mutation details: This transgene consists of 2 co-injected constructs. One encodes for a reverse tetracycline responsive transactivator with expression driven by a murine Gfap promoter. The second has a bidirectional tetracycline responsive promoter that drives expression of a lacZ reporter and a human MOAB cDNA. Several founders were generated and the line with the highest level of expression was used for analyses. Line 1 was generated. (J:132679)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:132679 Mallajosyula JK, et al., MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology. PLoS One. 2008;3(2):e1616
• All: 5 reference(s)