Tg(Upk2-TAg)1Rkl
Transgene Detail

Summary

• Symbol: Tg(Upk2-TAg)1Rkl
• Name: transgene insertion 1, Raghu Kalluri
• MGI ID: MGI:5014305
• Synonyms: UPK II-SV40
• Transgene: Tg(Upk2-TAg)1Rkl Location: unknown
• Alliance: Tg(Upk2-TAg)1Rkl page

Urothelial carcinoma in situ in Tg(Upk2-TAg)1Rkl/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse promoter drives urinary bladder-specific expression of the SV40 large T antigen with a polyadenylation sequence. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:173505)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173505 Ayala de la Pena F, et al., Loss of p53 and Acquisition of Angiogenic MicroRNA Profile Are Insufficient to Facilitate Progression of Bladder Urothelial Carcinoma in Situ to Invasive Carcinoma. J Biol Chem. 2011 Jun 10;286(23):20778-87
• All: 2 reference(s)