Tg(ACTB-Fig4*I41T)705Mm
Transgene Detail

Summary

• Symbol: Tg(ACTB-Fig4*I41T)705Mm
• Name: transgene insertion 705, Miriam H Meisler
• MGI ID: MGI:5014487
• Synonyms: FIG4-I41T, Tg705
• Transgene: Tg(ACTB-Fig4*I41T)705Mm Location: unknown
• Alliance: Tg(ACTB-Fig4*I41T)705Mm page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-Fig4*I41T)705Mm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fig4 (MGI:2143585)

• Mutation details: A chicken beta-actin promoter drives expression of a mouse Fig4 cDNA carrying an I41T mutation. This line carries 4 copies of the transgene. Expression levels of Fig4 transcripts were increased 3 fold over non-transgenic controls. (J:173446)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173446 Lenk GM, et al., Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J. PLoS Genet. 2011 Jun;7(6):e1002104
• All: 2 reference(s)