Tg(CMV-Tsc2*)1Arbi
Transgene Detail

Summary

• Symbol: Tg(CMV-Tsc2*)1Arbi
• Name: transgene insertion 1, Jack Arbiser
• MGI ID: MGI:5049894
• Synonyms: deltaRG
• Transgene: Tg(CMV-Tsc2*)1Arbi Location: unknown
• Alliance: Tg(CMV-Tsc2*)1Arbi page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Tsc2*)1Arbi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tsc2 (MGI:102548)

• Mutation details: The delta-RG (DRG) transgenic construct contains a mutant mouse Tsc2 (tuberous sclerosis 2) cDNA, lacking the sequence encoding the rabaptin-5 and rap1GAP motifs, under control of the CMV (cytomegalovirus) promoter. Line 1 was generated. (J:96943)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(CMV-Tsc2*)1Arbi/0	involves: C57BL/6

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
behavior/neurological	√
abnormal motor learning	√
abnormal social investigation	√
abnormal response to social novelty	√
integument	√
abnormal dermal layer morphology	√
increased skin hamartoma incidence	√
neoplasm	√
increased hamartoma incidence	√
increased skin hamartoma incidence	√
nervous system	√
abnormal cerebellum morphology	√
reduced long-term depression	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
tuberous sclerosis IDs tuberous sclerosis       DOID:13515 ICD10CM:Q85.1 ICD9CM:759.5 MESH:D014402 NCI:C3424 OMIM:PS191100 UMLS_CUI:C0041341 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96943 Govindarajan B, et al., Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain. J Biol Chem. 2005 Feb 18;280(7):5870-4
• All: 6 reference(s)