Mirc5 MGI Mouse Complex/Cluster/Region Detail - MGI:5049942 - microRNA cluster 5, including Mir290a through Mir295

Mirc5 Complex/Cluster/Region Detail

Symbol

Mirc5
Name

microRNA cluster 5, including Mir290a through Mir295
Synonyms

EEmiRC

Feature Type

complex/cluster/region
IDs

MGI:5049942
Cluster Members

Mir290a, Mir291a, Mir292 ... (7 members)

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Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 7, Syntenic

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Phenotype Summary

21 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
6 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display partial prenatal lethality, female infertility, impaired primordial germ cell migration, and reduced numbers of male and female germ cells; however, males are fertile.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

95
Tissues

63
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

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All nucleic 1

Primer pair 1

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miRBase

MI0000388, MI0000389, MI0000390, MI0000391, MI0000392, MI0000393, MI0003539

Summaries

All 12

Developmental Gene Expression 3

Phenotypes 6
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:245773 Paikari A, et al., The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743

Mirc5 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir290a, microRNA 290a	miRNA gene	Chr7:3267300-3267382 (+)
Mir291a, microRNA 291a	miRNA gene	Chr7:3267593-3267674 (+)
Mir292, microRNA 292	miRNA gene	Chr7:3267863-3267944 (+)
Mir291b, microRNA 291b	miRNA gene	Chr7:3268156-3268234 (+)
Mir293, microRNA 293	miRNA gene	Chr7:3269017-3269096 (+)
Mir294, microRNA 294	miRNA gene	Chr7:3269315-3269398 (+)
Mir295, microRNA 295	miRNA gene	Chr7:3269447-3269515 (+)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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