Tg(Mapt-MAPT*)#Hanr
Transgene Detail

Summary

• Symbol: Tg(Mapt-MAPT*)#Hanr
• Name: transgene insertion, Hanna Rosenmann
• MGI ID: MGI:5052111
• Synonyms: DM-htau
• Transgene: Tg(Mapt-MAPT*)#Hanr Location: unknown
• Alliance: Tg(Mapt-MAPT*)#Hanr page

Transgene origin

• Strain of Origin: C57BL/6 x BALB/c

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mapt-MAPT*)#Hanr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: A fragment of the rat Mapt promoter drives expression of a human MAPT cDNA coding for the short four repeat isoform, containing 2 pathogenic mutations, K257T and P301S. Expression of the mutant MAPT protein is about 5-10% that of the endogenous protein. (J:137947)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: tauopathy (J:137947)

References

• Original: J:137947 Rosenmann H, et al., A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol. 2008 Jul;212(1):71-84
• All: 4 reference(s)