Tg(Eno2-PSEN2)2348Ykk
Transgene Detail

Summary

• Symbol: Tg(Eno2-PSEN2)2348Ykk
• Name: transgene insertion 2348, Yong K Kim
• MGI ID: MGI:5052116
• Synonyms: NSE-hPS2w
• Transgene: Tg(Eno2-PSEN2)2348Ykk Location: unknown
• Alliance: Tg(Eno2-PSEN2)2348Ykk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-PSEN2)2348Ykk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN2 (5664)

  Psen2

  (MGI:109284)

• Mutation details: A 1.8kb fragment of the rat Eno2 promoter drives expression of a human PSEN2 cDNA. High levels of mRNA expression were detected in the brain. Expression in the liver, kidney and intestines were higher than in the brain. (J:76934)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76934 Hwang DY, et al., Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 2002 Jun;16(8):805-13
• All: 1 reference(s)