Tg(Eno2-PSEN2*)1480Ykk
Transgene Detail

Summary

• Symbol: Tg(Eno2-PSEN2*)1480Ykk
• Name: transgene insertion 1480, Yong K Kim
• MGI ID: MGI:5052118
• Synonyms: NSE-hPS2m
• Transgene: Tg(Eno2-PSEN2*)1480Ykk Location: unknown
• Alliance: Tg(Eno2-PSEN2*)1480Ykk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-PSEN2*)1480Ykk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN2 (5664)

  Psen2

  (MGI:109284)

• Mutation details: A 1.8kb fragment of the rat Eno2 promoter drives expression of a human PSEN2 cDNA with an N141I mutation found in Volga German families. The highest levels of transgene mRNA expression were detected in the anterior brain, followed by posterior brain, muscle, lung, heart, and liver. (J:76934)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76934 Hwang DY, et al., Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 2002 Jun;16(8):805-13
• All: 2 reference(s)