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Tg(HTT*/EGFP)190Nn
Transgene Detail
Summary
Symbol: Tg(HTT*/EGFP)190Nn
Name: transgene insertion 190, Nobuyuki Nukina
MGI ID: MGI:5052377
Synonyms: HD190QG
Transgene: Tg(HTT*/EGFP)190Nn  Location: unknown  
Alliance: Tg(HTT*/EGFP)190Nn page
Transgene
origin
Strain of Origin:  C57BL/6 x DBA/2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(HTT*/EGFP)190Nn expresses 1 gene
 
Mutation detailsThe human HTT promoter and exon 1, containing expanded CAG repeats, were fused to EGFP. The expanded repeat segment includes about 150 CAG repeats. This line carries 2 main fragments, one with 190 CAG repeats and one with 155 CAG repeats. (J:174269)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:174269 Kotliarova S, et al., Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. J Neurochem. 2005 May;93(3):641-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory