Tg(Pcp2-TBP*)69Hmhl
Transgene Detail

Summary

• Symbol: Tg(Pcp2-TBP*)69Hmhl
• Name: transgene insertion 69, Hsiu M Hsieh-Li
• MGI ID: MGI:5142235
• Synonyms: hTBP-109Q, L7-hTBP
• Transgene: Tg(Pcp2-TBP*)69Hmhl Location: unknown
• Alliance: Tg(Pcp2-TBP*)69Hmhl page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-TBP*)69Hmhl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TBP (6908)

  Tbp	(MGI:101838)

• Mutation details: This transgene consists of the full-length human TATA box binding protein, TBP, with the 36 CAA/CAG repeat region expanded to 109 repeats under the control of the mouse Pcp2 promoter. A copy number of 10-20 is seen for line 69. Expression of the transgene occurs mainly in the cerebellum and brainstem, and at lower levels in cortex and hippocampus. (J:174239)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four lines were made in J:174239, lines 20, 54, 69, and 71.

References

• Original: J:174239 Chang YC, et al., Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17. J Neurochem. 2011 Jul;118(2):288-303
• All: 2 reference(s)