Tg(SOD1*G127X)716Mrkl
Transgene Detail

Summary

• Symbol: Tg(SOD1*G127X)716Mrkl
• Name: transgene insertion 716, Stefan L Marklund
• MGI ID: MGI:5286585
• Synonyms: G127X, SOD1^G127insTGGG
• Transgene: Tg(SOD1*G127X)716Mrkl Location: unknown
• Alliance: Tg(SOD1*G127X)716Mrkl page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G127X)716Mrkl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: An 11.6 kb human SOD1 genomic fragment containing a mutation in exon 5 (Gly127insTGGG) that results in production of a truncated enzyme subunit with five novel amino acids following Gly127 was randomly inserted. This line carries 19 copies of the transgene. (J:175594)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175594 Jonsson PA, et al., Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis. Brain. 2004 Jan;127(Pt 1):73-88
• All: 9 reference(s)