Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
Transgene Detail

Summary

• Symbol: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
• Name: transgene insertion C63, David R Borchelt
• MGI ID: MGI:5286114
• Synonyms: N586-82Q-C63
• Transgene: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo Location: unknown
• Alliance: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The mouse promoter drives brain-specific expression of the human cDNA encoding the first 586 N-terminal amino acids (N586) and an expansion of the glutamine tract to 82 (82Q). The transgene was co-integrated with a transgene in which the human promoter drives skin-specific expression fo EGFP. Lines C62 and C63 were generated with the later expressing at higher levels than the former. (J:173756)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173756 Tebbenkamp AT, et al., Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Hum Mol Genet. 2011 Jul 15;20(14):2770-82
• All: 2 reference(s)