Del(7Slx1b-Sept1)4Aam Cytogenetic Marker Detail

Summary

• Symbol
  Del(7Slx1b-Sept1)4Aam
• Name
  deletion, Chr 7, Alea A Mills 4

• Feature Type
  chromosomal deletion
• IDs
  MGI:5291501

Location &
Maps

• Sequence Map
  Chr7:126288640-126832159 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, Syntenic

Human Diseases

• Diseases
  1 with Del(7Slx1b-Sept1)4Aam mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

autism spectrum disorder      

DOID:0060041
MESH:D000067877

View 2 models

Mouse Models

Human Disease Modeled: autism spectrum disorder

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(7Slx1b-Sept1)4Aam/+	involves: 129S7/SvEvBrd * C57BL/6N	J:176335	View
Del(7Slx1b-Sept1)4Aam/0	B6129S-Del(7Slx1b-Sept1)4Aam/J	J:219859	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 1 allele in 3 genetic backgrounds
  29 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice with this deletion exhibit decreased body size, hyperactivity, and stereotypic behavior.

References

• Summaries
  All 30

  Diseases 2

  Phenotypes 29
• Earliest
  J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17076-81
• Latest
  J:359305 Choi A, et al., Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. iScience. 2024 Dec 20;27(12):111285